40nm Protein A nanoparticle conjugate

Our 40nm gold nanoparticle Protein A conjugate is manufactured using our InnovaCoat® technology. We have coated our high quality gold nanoparticles with a proprietary surface coat that covalently binds the Protein A forming ultra stable conjugates. The attachment is irreversible meaning that there is no desorption of the antibody from the gold particle, which is a common problem associated with gold conjugates developed using passive adsorption techniques. InnovaCoat® GOLD Protein A 20nm binds to the Fc region of most mammalian IgG’s. Binding specificities and affinities can vary depending on source species and antibody subclasses.

Species Ig Binding Strength
Rabbit IgG High
Human IgG High
Pig IgG High
Mouse IgG1 Low/Medium
Mouse IgG2a High
Mouse IgG2b High
Mouse IgG3 Low/Medium
Goat IgG Low
Sheep IgG Low
Rat IgG Low

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