Ultra high quality gold nanoparticles
Innova Biosciences' Colloidal Gold
Gold nanoparticles are used in a variety of applications. In addition to lateral flow point-of-care assays, particles are also used in microscopy, flow cytometry, Raman spectroscopy and dynamic light scattering.
In all of these applications the use of high quality particles is vital. There are many sources of gold, both commercial and DIY, however Innova's colloidal gold has been rigorously tested against market-leading brands and shown to be superior.
- Uniform spherical shape
- Narrow size distribution
- Ultra high quality
- Batch-to-batch consistency
- High efficiency antibody binding for maximum sensitivity
- Available at high concentrations to simplify assay development
- Available in bulk quantities
Electron microscopy images of different 40nm gold particles demonstrating consistency of size and shape. Note the consistent size and shape of our gold nanoparticles (middle) compared to market leading competitor A (presence of hexagons and triangles) and market leading competitor B (highly inconsistent sized particles).
|Dark Field microscopy||●||Sphere|
|Metal enhanced fluorescence||●||Sphere/flat surface|
|Infrared phototermal therapy||●||Rod/hollow sphere|
Contact us to find out more:
- Technical enquiries – firstname.lastname@example.org
- Ordering - email@example.com
- Custom project requirements - firstname.lastname@example.org
Figure 2. Comparison of Innova Biosciences gold nanoparticles with those of a leading competitor in a lateral flow assay test for CRP. Two different monoclonal antibodies (clones C5 and C7) were conjugated to gold using identical techniques. Innova's gold colloid shows higher signal intensity than competitor gold with both antibodies, under identical conditions.
Figure 1. Comparison of Innova Biosciences gold particles with those from the market leading competitor. Both vials contain 40nm gold particles at 10OD/ml.
1 OD 10nm gold nanoparticles [More info]
1 OD 40nm gold nanoparticles [More info]
10 OD 10nm gold nanoparticles [More info]
10 OD 40nm gold nanoparticles [More info]
15 OD 40nm gold nanoparticles [More info]
20 OD 40nm gold nanoparticles [More info]
InnovaCoat® GOLD is a one-step gold nano-particle conjugation kit for antibodies, proteins and peptides or any other biomolecule with an amine group.
Commercially available antibodies often contain substances (e.g. BSA, glycine, tris, and azide) that interfere in labeling reactions. We have developed a range of purification kits which allow for easy and rapid purification of antibodies from any buffer formulation. All products are easy to use and are fully compatible with our nanoparticle kits.
1. What is the shelf life of Innova Biosciences Colloidal gold?
Our colloidal gold is guaranteed to be stable for up to two years from manufacturing in an unopened bottle stored at 4⁰C. It is recommended to use the colloidal gold within six months from opening.
2. What is the best storage condition?It is recommended to store the colloidal gold at 4⁰C and use them at room temperature. Freezing must be avoided as it leads to irreversible particle aggregation and the formation of a black precipitate.
3. Is it normal for nanoparticles to settle out of solution?
Yes, this can happen especially with larger size gold nanoparticles (40-80nm). The particles might settle at the bottom of the bottle, leaving a clear solution. This process is reversible: the particles can be resuspended by gently inverting the bottle a few times.
4. In which buffer are the nanoparticles provided?
Our colloidal gold nanoparticles undergo a buffer exchange to remove any residual manufacturing products and are suspended in citrate buffer.
5. How are the gold nanoparticles characterized?
Each batch of colloidal gold, both 10nm and 40nm sizes, is analysed by TEM and UV-Visible spectroscopy to ensure high quality standards. Particles specifications, such as mean size, standard deviation and coefficient of variation, are based on more than 100 single nanoparticle measurements.
6. What if I need more concentrated gold nanoparticles for my applications?
Colloidal gold can be centrifuged, but this might lead to aggregation and impossibility to resuspend the nanoparticles. Our range includes gold nanoparticles concentrated up to 20 OD, but upon request we can also manufacture colloidal gold at a higher OD.
Please get in touch for further information.
7. What is your production scale?
We are able to manufacture colloidal gold in bulk quantities to support any scale of operation, still keeping consistent our quality standards.
Please get in touch with us for further information and to request a quote.
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