Our GTP agarose resin contains GTP linked via the terminal phosphate group. The resin has a long (14-atom) hydrophilic spacer to facilitate interactions with biomolecules. Linkage of GTP via the terminal phosphate means that the immobilised ligand cannot be removed by phosphatases in crude extracts.

Recent publications citing GTP agarose:
Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations. J Neurosci. 2007 Jan 10;27(2):422-30